The American Journal of Medicine
Volume 115, Issue 1 , Pages 73-74 , July 2003

The reply:

  • Allen C. Steere, MD

      Affiliations

    • Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Vijay K. Sikand, MD

      Affiliations

    • Tufts University School of Medicine, Boston, Massachusetts, USA

References 

  1. Steere AC, Dhar A, Hernandez J, et al.  Systemic symptoms without erythema migrans as the presenting picture of early Lyme disease. Am J Med. 2003;114:58–62
  2. Steere AC, Bartenhagen NH, Craft JE, et al.  The early clinical manifestations of Lyme disease. Ann Intern Med. 1983;99:76–82
  3. Steere AC, Sikand VK, Meurice F, et al.  Vaccination against Lyme disease with recombinant outer-surface protein A in adjuvant. N Engl J Med. 1998;339:209–215
  4. Nocton JJ, Dressler F, Rutledge BJ, et al.  Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid in Lyme arthritis. N Engl J Med. 1994;330:229–234
  5. Nocton JJ, Bloom BJ, Rutledge BJ, et al.  Detection of Borrelia burgdorferi DNA by polymerase chain reaction in cerebrospinal fluid in patients with Lyme neuroborreliosis. J Infect Dis. 1996;174:623–627
  6. Klempner MS, Hu LT, Evans J, et al.  Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med. 2001;345:85–92
  7. Dressler F, Whalen JA, Reinhardt BN, Steere AC. Western blotting in the serodiagnosis of Lyme disease. J Infect Dis. 1993;167:392–400
  8. Liang FT, Steere AC, Marques AR, Johnson BJ, Miller JN, Philipp MT. Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi VlsE. J Clin Microbiol. 1999;37:3990–3996
  9. Krause PJ, Telford SR, Spielman A, et al.  Concurrent Lyme disease and babesiosis: evidence for increased severity and duration of illness. JAMA. 1996;275:1657–1660
  10. Krause PJ, McKay K, Thompson CA, et al.  Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin Infect Dis. 2002;34:1184–1191

PII: S0002-9343(03)00243-2

doi: 10.1016/S0002-9343(03)00243-2

The American Journal of Medicine
Volume 115, Issue 1 , Pages 73-74 , July 2003

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