The American Journal of Medicine
Volume 114, Issue 6 , Pages 511-512 , 15 April 2003

Grapefruit and tonic: a deadly combination in a patient with the long QT syndrome

References 

  1. Bigger JT, Hoffman BF. Antiarrhythmic drugs. In:  Gilman AG,  Goodman LS,  Rial TW, et al. editor. The Pharmacological Basis of Therapeutics. New York: MacMillan Press; 1985;p. 748–783
  2. Martin ES, Rogalski K, Black JN. Quinine may trigger torsades de pointes during astemizole therapy. Pacing Clin Electrophysiol. 1997;20(8):2024–2025
  3. Zhang H, Wong CW, Coville PF, Wanwimolruk S. Effects of the grapefruit flavonoid naringin on pharmacokinetics of quinine in rats. Drug Metab Drug Interact. 2000;17:351–363
  4. Min DI, Ku YM, Geraets DR, Lee LH. Effect on the grapefruit juice on the pharmacodynamics of quinidine in healthy volunteers. J Clin Pharmacol. 1996;36:469–476
  5. Ho PC, Chalcroft SC, Coville PF, Wanwimolruk S. Grapefruit has no effect on quinine pharmacokinetics. Eur J Clin Pharmacol. 1999;55:393–398
  6. Ewing DJ. Diabetic autonomic neuropathy and the heart. Diabetes Res Clin Pract. 1996;30(suppl):31–36
  7. Moss AJ, Schwartz PJ, Crampton RS, et al.  The long QT syndrome (a prospective international study). Circulation. 1985;71:17–21

PII: S0002-9343(03)00071-8

doi: 10.1016/S0002-9343(03)00071-8

The American Journal of Medicine
Volume 114, Issue 6 , Pages 511-512 , 15 April 2003

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