The American Journal of Medicine
Volume 112, Issue 5 , Pages 343-347 , 1 April 2002

Effects of calcium supplementation on serum lipid concentrations in normal older women: A randomized controlled trial

  • Ian R Reid, MD

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Barbara Mason

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Anne Horne, MB, ChB

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Ruth Ames

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Judith Clearwater

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Usha Bava

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Brandon Orr-Walker, MB, ChB

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Fiona Wu, MB, ChB

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Margaret C Evans

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand
    • ,
  • Gregory D Gamble

      Affiliations

    • Department of Medicine, University of Auckland, Auckland, New Zealand

Received 16 July 2001 ,Revised 14 November 2001 ,Accepted 30 November 2001.

References 

  1. Genant HK, Cooper C, Poor G, et al.  Interim report and recommendations of the World Health Organization task force for osteoporosis. Osteoporos Int. 1999;10:259–264
  2. Dawson-Hughes B, Dallal GE, Krall EA, et al.  A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med. 1990;323:878–883
  3. Reid IR, Ames RW, Evans MC, et al.  Effect of calcium supplementation on bone loss in postmenopausal women. N Engl J Med. 1993;328:460–464
  4. Chevalley T, Rizzoli R, Nydegger V, et al.  Effects of calcium supplements on femoral bone mineral density and vertebral fracture rate in vitamin-D-replete elderly patients. Osteoporos Int. 1994;4:245–252
  5. Reid IR, Ames RW, Evans MC, et al.  Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women—a randomized controlled trial. Am J Med. 1995;98:331–335
  6. Recker RR, Hinders S, Davies KM, et al.  Correcting calcium nutritional deficiency prevents spine fractures in elderly women. J Bone Miner Res. 1996;11:1961–1966
  7. Bargerlux MJ, Heaney RP. The role of calcium intake in preventing bone fragility, hypertension, and certain cancers. J Nutr. 1994;124(suppl):S1406–S1411
  8. Govers MJAP, Vandermeer R. Effects of dietary calcium and phosphate on the intestinal interactions between calcium, phosphate, fatty acids, and bile acids. Gut. 1993;34:365–370
  9. Denke MA, Fox MM, Schulte MC. Short-term dietary calcium fortification increases fecal saturated fat content and reduces serum lipids in men. J Nutr. 1993;123:1047–1053
  10. Mitchell WD, Fyfe T, Smith DA. The effect of oral calcium on cholesterol metabolism. J Atheroscler Res. 1968;8:913–922
  11. Yacowitz H, Fleischman AI, Bierenbaum ML. Effects of oral calcium on serum lipids in man. BMJ. 1965;1:1352–1354
  12. Carlson LA, Olsson AG, Oro L, Rossner S. Effects of oral calcium on serum cholesterol and triglycerides in patients with hyperlipidemia. Atherosclerosis. 1971;14:391–400
  13. Albanese AA, Edelson AH, Woodhull ML, et al.  Effect of a calcium supplement on serum cholesterol, calcium, phosphorus and bone density of normal healthy elderly females. Nutr Rep Int. 1973;8:119–130
  14. Bierenbaum ML, Fleischman AI, Raichelson RI. Long-term human studies on the lipid effects of oral calcium. Lipids. 1972;7:202–206
  15. Bostick RM, Fosdick L, Grandits GA, et al.  Effect of calcium supplementation on serum cholesterol and blood pressure—a randomized, double-blind, placebo-controlled, clinical trial. Arch Fam Med. 2000;9:31–38
  16. Angus RM, Sambrook PN, Pocock NA, Eisman JA. A simple method for assessing calcium intake in Caucasian women. J Am Diet Assoc. 1989;89:209–214
  17. Wilson PWF, Paffenbarger RS, Morris JN, Havlik RJ. Assessment methods for physical fitness and physical activity in population studies (report of a NHLBI workshop). Am Heart J. 1986;111:1177–1192
  18. Scandinavian Simvastatin Survival Study Group . Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease (the Scandinavian Simvastatin Survival Study (4S)). Lancet. 1994;344:1383–1389
  19. Shepherd J, Cobbe SM, Ford I, et al.  Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995;333:1301–1307
  20. Manninen V, Tenkanen L, Koskinen P, et al.  Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation. 1992;85:37–45
  21. Bell L, Halstenson CE, Halstenson CJ, et al.  Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia. Arch Intern Med. 1992;152:2441–2444
  22. Barr SI, McCarron DA, Heaney RP, et al.  Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults. J Am Diet Assoc. 2000;100:810–817
  23. Bostick RM, Kushi LH, Wu Y, et al.  Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol. 1999;149:151–161
  24. Knox EG. Ischaemic-heart-disease mortality and dietary intake of calcium. Lancet. 1973;ii:1465–1467
  25. Dawson EB, Frey MJ, Moore TD, McGanity WJ. Relationship of metal metabolism to vascular disease mortality rates in Texas. Am J Clin Nutr. 1978;31:1188–1197
  26. Ness AR, Smith GD, Hart C. Milk, coronary heart disease and mortality. J Epidemiol Community Health. 2001;55:379–382
  27. Zemel MB, Shi H, Greer B, et al.  Regulation of adiposity by dietary calcium. FASEB J. 2000;14:1132–1138
  28. Kelly KA, Gimble JM. 1,25-dihydroxy vitamin d-3 inhibits adipocyte differentiation and gene expression in murine bone marrow stromal cell clones and primary cultures. Endocrinology. 1998;139:2622–2628
  29. Grey AB, Evans MC, Stapleton JP, Reid IR. Body weight and bone mineral density in postmenopausal women with primary hyperparathyroidism. Ann Intern Med. 1994;121:745–749
  30. Davies KM, Heaney RP, Recker RR, et al.  Calcium intake and body weight. J Clin Endocrinol Metab. 2000;85:4635–4638
  31. McCarron DA, Morris CD, Henry HJ, Stanton JL. Blood pressure and nutrient intake in the United States. Science. 1984;224:1392–1398

☆ Funded by the Health Research Council of New Zealand.

PII: S0002-9343(01)01138-X

The American Journal of Medicine
Volume 112, Issue 5 , Pages 343-347 , 1 April 2002

Article Tools

* Image Usage & Resolution