The American Journal of Medicine
Volume 111, Issue 8, Supplement 1 , Pages 78-84 , 3 December 2001

Update on gastroesophageal reflux disease in pediatric airway disorders

  • Robert F Yellon, MD

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Robert F. Yellon, MD, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213 USA
    • Department of Pediatric Otolaryngology, Children’s Hospital of Pittsburgh, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  • ,
  • Howard Goldberg, MD

      Affiliations

    • Department of Pediatric Otolaryngology, Children’s Hospital of Pittsburgh, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

References 

  1. Andze GO, Brandt ML, St Vil D, et al.  Diagnosis and treatment of gastroesophageal reflux in 500 children with respiratory symptoms (the value of pH monitoring). J Pediatr Surg. 1991;26:295–299
  2. Rudolph C, Mazur LJ, Liptak GS, et al.  Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children. Recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2001;32(suppl 2):S1–S32
  3. Contencin P, Narcy P. Nasopharyngeal pH monitoring in infants and children with chronic rhinopharyngitis. Int J Pediatr Otorhinolaryngol. 1991;22:249–256
  4. Putnam PE, Orenstein SR. Blind esophageal suction biopsy in children less than 2 years of age. Gastroenterology. 1992;102:A149
  5. Nussbaum E, Maggi JC, Mathis R, Galant SP. Association of lipid-laden alveolar macrophages and gastroesophageal reflux in children. J Pediatr. 1987;110:190–194
  6. Yellon RF, Coticchia J, Dixit S. Esophageal biopsy for the diagnosis of gastroesophageal reflux-associated otolaryngologic problems in children. Am J Med. 2000;108(suppl 4):131S–138S
  7. Dahms BB. Reflux esophagitis and sequelae in infants and children. In:  Dahms BB,  Qualman SJ editor. Perspectives in Pediatric Pathology. vol. 20:Basel, Switzerland: S Karger AG; 1997;p. 14–34
  8. Ruth M, Carlsson S, Mansson I, et al.  Scintigraphic detection of gastro-pulmonary aspiration in patients with respiratory disorders. Clin Physiol. 1993;13:19–33
  9. Hu FZ, Preston RA, Post JC, et al.  Mapping of a gene for severe pediatric gastroesophageal reflux to chromosome 13q14. JAMA. 2000;284:325–334
  10. Puntis JW, Smith HL, Buick RG, Booth IW. Effect of dystonic movements on oesophageal peristalsis in Sandifer’s syndrome. Arch Dis Child. 1989;64:1311–1313
  11. DiBaise JK, Huerter JV, Quigley EM. Sinusitis and gastroesophageal reflux disease. [letter] Ann Intern Med. 1998;129:1078
  12. Holinger LD, Sanders AD. Chronic cough in infants and children (an update). Laryngoscope. 1991;101:596–605
  13. Putnam PE, Orenstein SR. Hoarseness in a child with gastroesophageal reflux. Acta Paediatr. 1992;81:635–636
  14. Hanson DG, Kamel PL, Kahrilas PJ. Outcomes of antireflux therapy for the treatment of chronic laryngitis. Ann Otol Rhinol Laryngol. 1995;104:550–555
  15. Kuhn J, Toohill RJ, Ulualp SO, et al.  Pharyngeal acid reflux events in patients with vocal cord nodules. Laryngoscope. 1998;108:1146–1149
  16. Bouchard S, Lallier M, Yazbeck S, Bensoussan A. The otolaryngologic manifestations of gastroesophageal reflux (when is a pH study indicated?). J Pediatr Surg. 1999;34:1053–1056
  17. Cherry J, Margulies SI. Contact ulcer of the larynx. Laryngoscope. 1968;78:1937–1940
  18. Delahunty JE, Cherry J. Experimentally produced vocal cord granulomas. Laryngoscope. 1968;78:1941–1947
  19. Wang W, Tovar JA, Eizaguirre I, Aldazabal P. Airway obstruction and gastroesophageal reflux (an experimental study on the pathogenesis of this association). J Pediatr Surg. 1993;28:995–998
  20. Herbst JJ, Minton SD, Book LS. Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. J Pediatr. 1979;95:763–768
  21. Gorrotxategi P, Eizaguirre I, Saenz de Ugarte A, et al.  Characteristics of continuous esophageal pH-metering in infants with gastroesophageal reflux and apparent life-threatening events. Eur J Pediatr Surg. 1995;5:136–138
  22. Ing AJ, Ngu MC, Breslin AB. Obstructive sleep apnea and gastroesophageal reflux. Am J Med. 2000;108(suppl 4):120S–125S
  23. Waki EY, Madgy DN, Belenky WM, Gower VC. The incidence of gastroesophage al reflux in recurrent croup. Int J Pediatr Otorhinolaryngol. 1995;32:223–232
  24. Contencin P, Narcy P. Gastropharyngeal reflux in infants and children (a pharyngeal pH monitoring study). Arch Otolaryngol Head Neck Surg. 1992;118:1028–1030
  25. Andrieu-Guitrancourt J, Dehesdin D, Le Luyer B, et al.  Role of gastroesophageal reflux in acute recurrent laryngeal dyspnea in children. Ann Otolaryngol Chir Cervicofac. 1984;101:141–149
  26. Belmont JR, Grundfast K. Congenital laryngeal stridor (laryngomalacia) (etiologic factors and associated disorders). Ann Otol Rhinol Laryngol. 1984;93:430–437
  27. Polonovski JM, Contencin P, Francois M, et al.  Aryepiglottic fold excision for the treatment of severe laryngomalacia. Ann Otol Rhinol Laryngol. 1990;99:625–627
  28. Gonzalez C, Reilly JS, Bluestone CD. Synchronous airway lesions in infancy. Ann Otol Rhinol Laryngol. 1987;96:77–80
  29. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD) (a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury). Laryngoscope. 1991;l01(suppl 53):1–78
  30. Orenstein SR, Orenstein DM, Whitington PF. Gastroesophageal reflux causing stridor. Chest. 1983;84:301–302
  31. Nielson DW, Heldt GP, Tooley WH. Stridor and gastroesophageal reflux in infants. Pediatrics. 1990;85:1034–1039
  32. Henry RL, Mellis CM. Resolution of inspiratory stridor after fundoplication (case report). Aust Paediatr J. 1982;18:126–127
  33. Orenstein SR, Kocoshis SA, Orenstein DM, Proujansky R. Stridor and gastroesophageal reflux (diagnostic use of intraluminal esophageal acid perfusion (Bernstein test)). Pediatr Pulmonol. 1987;3:420–424
  34. Orenstein SR, Orenstein DM. Gastroesophageal reflux and respiratory disease in children. J Pediatr. 1988;112:847–858
  35. Sasaki CT, Horiuchi M, Koss N. Tracheostomy-related subglottic stenosis (bacteriologic pathogenesis). Laryngoscope. 1979;89:857–865
  36. Squire R, Brodsky L, Rossman J. The role of infection in the pathogenesis of acquired tracheal stenosis. Laryngoscope. 1990;100:765–770
  37. Borowiecki B, Croft CB. Experimental arrival model of subglottic stenosis. Ann Otol Rhinol Laryngol. 1977;86:835–840
  38. Little FB, Koufman JA, Kohut RI, Marshall RB. Effect of gastric acid on the pathogenesis of subglottic stenosis. Ann Otol Rhinol Laryngol. 1985;94:516–519
  39. Wynne JW, Ramphal R, Hood CI. Tracheal mucosal damage after aspiration (a scanning electron microscope study). Am Rev Respir Dis. 1981;124:728–732
  40. Gaynor EB. Gastroesophageal reflux as an etiologic factor in laryngeal complications of intubation. Laryngoscope. 1988;98:972–979
  41. Yellon RF, Szeremeta W, Grandis JR, et al.  Subglottic injury, gastric juice, corticosteroids, and peptide growth factors in a porcine model. Laryngoscope. 1998;108:854–862
  42. Jindal JR, Milbrath MM, Shaker R, et al.  Gastroesophageal reflux disease as a likely cause of “idiopathic” subglottic stenosis. Ann Otol Rhinol Laryngol. 1994;103:186–191
  43. Yellon RF, Parameswaran M, Brandom BW. Decreasing morbidity following laryngotracheal reconstruction in children. Int J Pediatr Otorhinolaryngol. 1997;41:145–154
  44. Aronow E, Silverberg M. Normal and abnormal GI motility. In:  Silverberg M editors. Pediatric Gastroenterology. New York: Medical Examination Publishing; 1983;p. 214
  45. Zalzal GH, Choi SS, Patel KM. The effect of gastroesophageal reflux on laryngotracheal reconstruction. Arch Otolaryngol Head Neck Surg. 1996;122:297–300

PII: S0002-9343(01)00861-0

The American Journal of Medicine
Volume 111, Issue 8, Supplement 1 , Pages 78-84 , 3 December 2001