The American Journal of Medicine
Volume 110, Issue 6 , Pages 486-488 , 15 April 2001

Association of tumor necrosis factor-2 allele with plasma tumor necrosis factor-alpha levels and mortality from septic shock

  • O Appoloni, MD

      Affiliations

    • Department of Intensive Care (OA, JLV), Erasme University Hospital, Brussels, Belgium
    • ,
  • E Dupont, MD, PhD

      Affiliations

    • Department of Immunology (ED, MV, MA), Erasme University Hospital, Brussels, Belgium
    • ,
  • M Vandercruys, RT

      Affiliations

    • Department of Immunology (ED, MV, MA), Erasme University Hospital, Brussels, Belgium
    • ,
  • M Andriens, BS

      Affiliations

    • Department of Immunology (ED, MV, MA), Erasme University Hospital, Brussels, Belgium
    • ,
  • J Duchateau, MD, PhD

      Affiliations

    • Department of Immunology (JD), Brugmann Hospital, Free University of Brussels, Brussels, Belgium
    • ,
  • Jean-Louis Vincent, MD, PhD

      Affiliations

    • Department of Intensive Care (OA, JLV), Erasme University Hospital, Brussels, Belgium
    • Corresponding Author InformationCorrespondence should be addressed to Jean-Louis Vincent, MD, PhD, Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B-1070 Brussels, Belgium

Received 7 July 2000 ,Revised 9 January 2001

References 

  1. Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time?. Crit Care Med. 1998;26:2078–2086
  2. Wilson AG, Symons JA, McDowell TL, et al.  Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA. 1997;94:3195–3199
  3. Kroeger KM, Carville KS, Abraham LJ. The −308 tumor necrosis factor-alpha promoter polymorphism affects transcription. Mol Immunol. 1997;34:391–399
  4. Warzocha K, Ribeiro P, Bienvenu J, et al.  Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin’s lymphoma outcome. Blood. 1998;91:3574–3581
  5. Louis E, Franchimont D, Piron A, et al.  Tumor necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol. 1998;113:401–406
  6. Brinkman BM, Zuijdeest D, Kaijzel EL, et al. Relevance of the tumor necrosis factor alpha (TNF alpha) −308 promoter polymorphism in TNF alpha gene regulation. J Inflamm. 1995;46:32–41.
  7. Kroeger KM, Steer JH, Joyce DA, et al.  Effects of stimulus and cell type on the expression of the −308 tumour necrosis factor promoter polymorphism. Cytokine. 2000;12:110–119
  8. McGuire W, Hill AV, Allsopp CE, et al.  Variation of the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature. 1994;371:508–510
  9. Cabrera M, Shaw MA, Sharples C, et al.  Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. J Exp Med. 1995;182:1259–1264
  10. Stüber F, Udalova IA, Book M, et al.  −308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human promoter. J Inflammation. 1996;46:42–50
  11. Westendorp RG, Langermans JA, Huizinga TW, et al.  Genetic influence on cytokine production and fatal meningococcal disease. Lancet. 1997;349:170–173
  12. Mira JP, Cariou A, Grall F, et al.  Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality (a multicenter study). JAMA. 1999;282:561–568
  13. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993;270:2957–2963
  14. Moreno R, Vincent JL, Matos R, et al.  The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis-related Problems of the ESICM. Intens Care Med. 1999;25:686–696
  15. Dhainaut JF, Vincent JL, Richard C, et al.  CDP571, a humanized antibody to human tumor necrosis factor-alpha (safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock). Crit Care Med. 1995;23:1461–1469

PII: S0002-9343(01)00656-8

The American Journal of Medicine
Volume 110, Issue 6 , Pages 486-488 , 15 April 2001

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