The American Journal of Medicine
Volume 81, Issue 6 , Pages 983-988 , December 1986

Serum, lymphocyte, and erythrocyte potassium, magnesium, and calcium concentrations and their relation to tachyarrhythmias in patients with acute myocardial infarction

Received 16 July 1985 ,Accepted 16 September 1985.

References 

  1. Abraham AS, Eylath U, Weinstein M, Czackes E. Serum magnesium levels in patients with acute myocardial infarction. N Engl J Med. 1977;296:862–863
  2. Dyckner T. Serum magnesium in acute myocardial infarction. Acta Med Scand. 1980;207:59–66
  3. Iseri LT, Freed J, Bures AR. Magnesium deficiency and cardiac disorders. Am J Med. 1975;58:837–846
  4. Singh R, Dube K, Srivastov P. Hypomagnesemia in relation to digoxin intoxication in children. Am Heart J. 1976;92:144–147
  5. Cohen L, Kitzes R. Magnesium sulfate and digitalis toxic arrhythmias. JAMA. 1983;249:2808–2810
  6. Bigg RPC, Chia R. Magnesium deficiency. In: Role in arrhythmias complicating acute myocardial infarction. Med J Aust. 1:1981;p. 346–348
  7. Dyckner T, Wester PO. Ventricular extrasystoles and intracellular electrolytes before and after potassium and magnesium infusions in patients on diuretic treatment. Am Heart J. 1969;97:12–18
  8. Baron DN. Down with plasma!. In: Intracellular chemical pathology studied by analysis of erythrocytes, leucocytes and cells of solid tissues. Proc R Soc Med. 62:1969;p. 945–953
  9. Ryan MP, Ryan MF. Lymphocyte electrolyte alterations during magnesium deficiency in the rat (abstr). Ir J Med Sci. 1979;148:108
  10. Ryan MP, Ryan FR, Counihan TB. The effect of diuretics on lymphocyte magnesium and potassium. Acta Med Scand. 1981;209(suppl 647):153–169
  11. Tufts EV, Greenberg DM. The biochemistry of magnesium deficiency. I. Chemical changes resulting from magnesium deprivation. J Biol Chem. 1938;122:693–726
  12. Elin JR, Armstrong WD, Singer L. Enzyme adenosine triphosphate and blood cellular changes in magnesium deficient and control rats. In: Proc Soc Exp Biol Med. 137:1971;p. 635–640
  13. Lown B. Cardiovascular collapse and sudden cardiac death. In:  Braunwald E editors. Heart disease. Philadelphia: WB Saunders; 1980;p. 778–817
  14. Boyum A. Separation of leucocytes from blood and bone marrow. Scand J Clin Lab Invest. 1968;21(suppl 97):9–29
  15. Abraham AS, Eylath U, Rosenman D, Meshulam Z, Brisk R. Lymphocyte and erythrocyte concentrations of potassium, magnesium and calcium in normal controls. Magnesium. 1985;4:102–105
  16. Brown MJ, Brown DC, Murphy MB. Hypokalemia from beta2-receptor stimulation by circulating epinephrine. N Engl J Med. 1983;309:1414–1419
  17. Rayssiguier Y. Hypomagnesemia resulting from adrenaline infusions in ewes. In: Its relation to lipolysis. Horm Metab Res. 9:1977;p. 309–314
  18. Elliott DA, Rizack MA. Epinephrine and adrenocorticotropic hormone stimulated magnesium accumulation in adipocytes and their plasma membranes. J Biol Chem. 1974;249:3895–3900
  19. Abraham AS, Shaoul R, Shimonovitz S, Eylath U, Weinstein M. Serum magnesium levels in acute medical and surgical conditions. Biochem Med. 1980;24:21–26
  20. Speich M, Bousquet B, Nicolas G. Concentrations of magnesium, calcium, potassium and sodium in human heart muscle after acute myocardial infarction. Clin Chem. 1980;12:1662–1665
  21. Chipperfield B, Chipperfield JR. Heart muscle magnesium, potassium and zinc concentrations after sudden death from heart disease. Lancet. 1973;II:293–296
  22. Cummings JR. Electrolyte changes in heart tissue and coronary arterial and venous plasma following coronary occlusions. Circ Res. 1960;8:865–870
  23. Shen AC, Jennings RB. Kinetics of calcium accumulation in acute myocardial ischemic injury. Am J Pathol. 1972;67:441–452
  24. Hirche HJ, Franz L, Bos R, Bissing RL, Schramm M. Myocardial extracellular K+ and H+ increase and noradrenaline release as possible cause of early arrhythmias following acute coronary artery occlusion in pigs. J Mol Cell Cardiol. 1980;12:579–593
  25. Watanabe Y, Dreifus LS. Electrophysiological effects of potassium and its interactions with potassium. Cardiovasc Res. 1972;6:79–88
  26. Woods WT, Katholi RE, Urthaler F, James TN. Electrophysiological effects of magnesium in cells in the canine sinsu node and false tendon. Circ Res. 1979;44:182–188
  27. Kraft LF, Katholi RE, Woods WT, James TN. Attenuation by magnesium of the electrophysiological effects of hyperkalemia on human and canine heart cells. Am J Cardiol. 1980;45:1189–1195
  28. Shine KI, Douglas AM. Magnesium effects on ionic exchange and mechanical function in rat ventricle. Am J Physiol. 1974;227:317–322
  29. Ghani MF, Rabah M. Effect of magnesium chloride on electrical stability of the heart. Am Heart J. 1977;94:600–602
  30. Covino BG, Hegnauer AH. Electrolytes and pH changes in relation to hypothermic ventricular fibrillation. Circ Res. 1955;3:575–580
  31. Fisch C. Relation of electrolyte disturbances to cardiac arrhythmias. Circulation. 1973;47:408–419
  32. Bunton RW. Value of serum magnesium estimation in diagnosing myocardial infarction and predicting dysrhythmias after coronary artery bypass grafting. Thorax. 1983;38:946–950

 This work was supported by grants from Merck, Sharp, and Dohme Research Laboratories, the Wolinsky Bessin research fund, and the National Council for Research and Development, Israel.

PII: 0002-9343(86)90392-X

The American Journal of Medicine
Volume 81, Issue 6 , Pages 983-988 , December 1986