The American Journal of Medicine
Volume 81, Issue 6 , Pages 959-961, December 1986

Role of the spleen in the transdiaphragmatic spread of Hodgkin's disease

  • J.L. Mann, M.D.

      Affiliations

    • Current address: Department of Laboratory Medicine, Memorial Medical Center, Springfield, Illinois 62781.
    • ,
  • G.R. Hafez, M.D.

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dr. G. R. Hafez, Department of Pathology, E5/317 Clinical Sciences Center, University of Wisconsin, 600 Highland Avenue, Madison, Wisconsin 53792.
    • ,
  • W.L. Longo, M.D.

Departments of Pathology and Human Oncology, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA

Received 11 December 1985; accepted 13 January 1986.

Abstract 

Results of detailed staging laparotomy for Hodgkin's disease with supradiaphragmatic presentation in 78 patients showed 28 with subdiaphragmatic involvement. All 28 patients with intra-abdominal disease had splenic involvement. On the basis of findings of this study and published series on staging laparotomy, it is proposed that the spleen is the first site of intra-abdominal disease in this group of patients, and that Hodgkin's disease spreads to the intra-abdominal lymph nodes, liver, and bone marrow from the spleen.

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PII: 0002-9343(86)90387-6

The American Journal of Medicine
Volume 81, Issue 6 , Pages 959-961, December 1986

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