The American Journal of Medicine
Volume 76, Issue 6 , Pages 1097-1099, June 1984

Acute basophilic leukemia☆

  • Ila Shah, M.D.

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dr. Ila Shah, Wayne State University School of Medicine, Hutzel Hospital, 4707 St. Antoine, Detroit, Michigan 48201.
    • From the Department of Medicine, Wayne State University School of Medicine, and Hutzel Hospital, Detroit, Michigan.
    • ,
  • Lawrence M. Lewkow, M.D.

      Affiliations

    • From the Department of Medicine, Wayne State University School of Medicine, and Hutzel Hospital, Detroit, Michigan.
    • ,
  • Fred Koppitch, B.A.

      Affiliations

    • From the Department of Medicine, Wayne State University School of Medicine, and Hutzel Hospital, Detroit, Michigan.

Detroit, Michigan USA

Accepted 23 June 1983.

Abstract 

Acute basophilic leukemia was diagnosed in a 61-year-old black woman on the basis of 85 to 90 percent basophils in the peripheral blood as well as bone marrow and very high serum histamine level (more than 10,000 ng/ml). These complications occurred as a transformation from essential thrombocythemia. Accompanying this transformation, there was also cytogenetic change from 46XX karyotype to 46XX 2p+ in 66 to 90 percent of cells in the bone marrow. This may be the first reported occurrence of transformation of essential thrombocythemia into acute basophilic leukemia.

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☆ This work was supported by Hutzel Hospital Research and Education Fund 205.

PII: 0002-9343(84)90864-7

The American Journal of Medicine
Volume 76, Issue 6 , Pages 1097-1099, June 1984

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