The American Journal of Medicine
Volume 76, Issue 6 , Pages 1013-1020 , June 1984

Second primary bronchogenic carcinomas after small cell carcinoma: Report of two cases and review of the literature

  • Johnny Craig, M.D.

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dr. Johnny Craig, Department of Medicine, Section on Hematology/Oncology, Bowman Gray School of Medicine, Wake Forest University, 300 South Hawthorne Road, Winston-Salem, North Carolina 27103.
    • From the Section on Hematology/Oncology, Department of Pathology, and Department of Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
    • ,
  • Bayard Powell, M.D.

      Affiliations

    • From the Section on Hematology/Oncology, Department of Pathology, and Department of Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
    • ,
  • Hyman B. Muss, M.D.

      Affiliations

    • From the Section on Hematology/Oncology, Department of Pathology, and Department of Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
    • ,
  • Ernest Kawamoto, M.D.

      Affiliations

    • From the Section on Hematology/Oncology, Department of Pathology, and Department of Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
    • ,
  • Robert Breyer, M.D.

      Affiliations

    • From the Section on Hematology/Oncology, Department of Pathology, and Department of Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.

,Accepted 6 January 1984.

References 

  1. Billroth T, Winiwarter A. Die allgemeine chirurgische Pathologie un Therapie in 51 Vorlesungen. In: 10th ed.  Billroth T,  Winiwarter A editor. Handbuck für Studirende and Hertze. vol 14G:Berlin: Reimer; 1914;p. 908–937
  2. Fauvet J, Chavy A, Piet R. Les cancers primitifs multiples. Rev Prat (Paris). 1964;14:2149–2174
  3. Freid BM. Primary multiple cancers. Arch Surg. 1968;77:730–741
  4. Mertel CG. Incidence and significance of multiple primary malignant neoplasms. Ann NY Acad Sci. 1964;114:886–895
  5. Thoma GW. The incidence and significance of multiple primary malignant tumors. Am J Med Sci. 1964;247:427–430
  6. Warren S, Gates O. Multiple malignant tumors. Am J Cancer. 1932;16:1358–1403
  7. Knudson RJ, Hatch H, Ochsner A, LeJeune F. Multiple carcinomas of the lung and upper respiratory tract. Dis Chest. 1965;48:140–144
  8. Leafstedt SW, Sweetman WR, Chester CL, Thorpe JD. Multiple primary neoplasms of the lung. J Thorac Cardiovasc Surg. 1968;55:626–633
  9. Hughes RK, Blades B. Multiple primary bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1961;41:421–429
  10. Shanker PS, Scott J, Andersen C. Metachronous ipsilateral primary neoplasms of the lung. CA. 1980;30:302–304
  11. Shields TW, Drake CT, Sherrick JC. Bilateral primary bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1964;48:401–407
  12. Caceres J, Felson B. Double primary carcinomas of the lung. Radiology. 1972;102:45–50
  13. Castleman B. In: Weekly clinicopathological conference. 10th ed. N Engl J Med. 277:1967;p. 147–154
  14. Guillan RA. Multiple primary bronchogenic carcinoma. J Kans Med Soc. 1978;11:563–564
  15. Onuigbo W. Multiple carcinomata of the lung. Br J Dis Chest. 1962;56:144–147
  16. Merrick D, Carr D, Payne W, Woolner L. Multiple primary cancer of the lung. Geriatrics. 1972;16:71–79
  17. Smith RA. Development and treatment of fresh lung carcinoma after successful lobectomy. Thorax. 1966;2:1–20
  18. Langston H, Sherrick J. Bilateral simultaneous bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1962;43:742–751
  19. Bower S, Choplin R, Muss H. Multiple primary bronchogenic carcinomas of lung. Am J Radiol. 1983;140:253–258
  20. Coffman B, Crum E, Forman W. Two primary carcinomas of the lung: adenocarcinoma and a metachronous squamous cell carcinoma. Cancer. 1983;51:124–126
  21. Ebihara Y, Fukushima N, Asakuma Y. Double primary lung cancers. Acta Cytol (Baltimore). 1980;24:212–223
  22. Beal J. Second primary lung tumors. IMJ. 1975;11:603–605
  23. Glennie J, Harvey P, Salama V. Multiple primary carcinoma of the bronchus. J Thorac Cardiovasc Surg. 1964;48:40–48
  24. Bilateral primary invasive carcinoma of the lungs. Dis Chest. 1961;39:421–424
  25. Watson A, Cameron E, Percy J. Multiple primary bronchial carcinoma—report of two cases and a review. Br J Dis Chest. 1964;58:181–187
  26. Robinson C, Jackson C. Multiple primary cancer of the lung. J Thorac Cardiovasc Surg. 1958;36:166–173
  27. Lehman J, Cross F. Bilateral multiple carcinoma of the lung. Cancer. 1966;19:1931–1936
  28. Martini N, Melamed M. Multiple primary lung cancers. J Thorac Cardiovasc Surg. 1975;70:606–612
  29. Auerbach O, Stout A, Hammond E, Garfinkel L. Multiple primary bronchial carcinomas. Cancer. 1967;20:699–706
  30. Rohwedder J, Weatherbee L. Multiple primary bronchogenic carcinoma with a review of the literature. Am Rev Respir Dis. 1974;109:435–445
  31. Struve-Christensen E. Diagnosis and treatment of bilateral primary bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1971;61:501–512
  32. Smith RA, Nigrain B, Thompson J. Second primary lung carcinoma. Thorax. 1976;31:507–513
  33. Jensik R, Faber L, Kittle C, Meng R. Survival following resection for second primary bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1981;82:658–668
  34. Salem T, Mumo D, Blundell P, Chiu R. Second primary brochogenic carcinoma: life-table analysis of surgical treatment. Ann Thorac Surg. 1979;27:3–8
  35. LeGal Y, Bauer W. Second primary bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1961;41:114–124
  36. Shields T, Humphrey E, Higgins G, Keehn R. Long-term survivors after resection of lung carcinoma. J Thorac Cardiovasc Surg. 1978;76:439–445
  37. Martini N, Melamed M. Multiple primary lung cancers. J Thorac Cardiovasc Surg. 1975;70:606–612
  38. Foucot K, Weiss W, Cooper D. Second pulmonary neoplasms among long-term survivors of lung cancer. Am Rev Respir Dis. 1965;92:767–774
  39. Mobley D, Martinez J. Two histologically different primary carcinomas of the lung. Cancer. 1968;22:287–292
  40. Billroth T, von Winiwarter A. General surgical pathology and therapeutics. In: 10th ed. New York: D. Appleton; 1883;p. 765;(translated from 4th German ed)
  41. McGrath E, Gall E, Kessler D. Bronchogenic carcinoma: a product of multiple sites of origin. J Thorac Cardiovasc Surg. 1952;24:271–283
  42. Abeloff M, Eggleston J, Messelsohn G, Ettinger D, Baylin S. Changes in morphologic and biochemical characteristics of small cell carcinoma of the lung. Am J Med. 1979;66:757–763
  43. Brereton H, Matthews M, Corta J, Kent H, Johnson R. Mixed anaplastic small cell and squamous cell carcinoma of the lung. Ann Intern Med. 1978;88:805–806
  44. Kainberger F. Uber einen Fall von doppeltern Brochuskarzinom. Klin Med (Mosk). 1955;10:354–360
  45. Rossman P. A case of double carcinoma of the lung in a heavy smoker (abstr). Excerpta Medica. 1960;13:930
  46. Feinstein A, Gelfman N, Yerner R. Observer variability in the histolpathologic diagnosis of lung cancer. Am Rev Respir Dis. 1970;101:671–684
  47. Shimosato Y. Pathology of lung cancer. In: 3rd ed.  Kuro M,  Ishikawa S editor. Atlas of lung cancers. Tokyo: Nakayama Press; 1968;p. 299–313
  48. Minna J, Higgins G, Glatstein E. Cancer of the lung. In:  DeVita V,  Hellman S,  Rosenberg S editor. Cancer: principles and practice of oncology. Philadelphia: JB Lippincott; 1982;p. 396–474
  49. Yesner R. A unified concept of lung cancer histopathology (abstr). In: 3rd ed. Proc Am Soc Clin Oncol. 18:1977;p. 271
  50. Yesner R. The dynamic histopathologic spectrum of lung cancer. Yale J Biol Med. 1981;54:447–456
  51. Seeger R, Siegel S, Sidell N. Neuroblastoma: clinical perspectives, monoclonal antibodies and retinoic acid. Ann Intern Med. 1982;97:873–884
  52. Hong WK, Wittes R, Hojdu S, Cvitkovic E, Whitmore W, Golbey R. The evolution of mature teratoma from malignant testicular tumors. Cancer. 1977;40:2987–2992
  53. Volk SA, Mansour RP, Gandara DR, Redmond J. Morbidity in long-term survivors of small cell carcinoma of the lung (abstr). In: 3rd ed. Proc Am Soc Clin Oncol/Proc Am Soc Cancer Res. 2:1983;p. 185

☆ This work was supported in part by National Cancer Institute Grant CA-12197 and American Cancer Society Grant CF-5567.

PII: 0002-9343(84)90850-7

The American Journal of Medicine
Volume 76, Issue 6 , Pages 1013-1020 , June 1984

Article Tools