The American Journal of Medicine
Volume 74, Issue 6 , Pages 1016-1022 , June 1983

Vigorous supplementation of a hypocaloric diet prevents cardiac arrhythmias and mineral depletion

  • John M. Amatruda, M.D.

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dr. John M. Amatruda, Endocrine-Metabolism Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642.
    • From the Endocrine-Metabolism and Cardiology Units, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
    • Dr. Amatruda is the recipient of a United States Public Health Service Research Career Development Award (AM 00366).
    • ,
  • Theodore L. Biddle, M.D.

      Affiliations

    • From the Endocrine-Metabolism and Cardiology Units, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
    • ,
  • Mary L. Patton, M.D.

      Affiliations

    • From the Endocrine-Metabolism and Cardiology Units, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
    • ,
  • Dean H. Lockwood, M.D.

      Affiliations

    • From the Endocrine-Metabolism and Cardiology Units, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.

,Accepted 25 August 1982.

References 

  1. Singh BN, Gaarder TO, Kanegae T, Goldstein M, Montgomerie JZ, Mills H. Liquid protein diets and torsade de pointes. JAMA. 1978;240:115–119
  2. Brown JM, Yeter JF, Spicer MJ, Jones IO. Cardiac complications of protein-sparing modified fasting. JAMA. 1978;240:120–122
  3. Michiel RR, Sneider JS, Dickstein RA, Hagman HH, Eich RH. Sudden death in a patient on a liquid protein diet. N Engl J Med. 1978;298:1005–1007
  4. Isner JM, Sours HE, Paris AL, Ferrans VJ, Roberts WC. Sudden, unexpected death in avid dieters using the liquid-protein-modified-fast diet. Circulation. 1979;60:1401–1412
  5. Lantigua RA, Amatruda JM, Biddle TL, Forbes GB, Lockwood DH. Cardiac arrhythmias associated with a liquid protein diet for the treatment of obesity. N Engl J Med. 1980;303:735–738
  6. Moldawer LL, Beauregard K, Bistrian BR, Blackburn GL. Role of micronutrient intake in cardiac changes produced by “liquid protein”. Clin Res. 1979;27:593A
  7. Joint FAO/WHO Expert Committee . Energy and protein requirements. WHO Chron. 1973;27:481–486
  8. Apfelbaum M. The effects of very restrictive high protein diets. Clin Endocrinol Metab. 1976;5:417–430
  9. Bistrian BR, Winterer J, Blackburn GL, Young V, Sherman M. Effect of a protein-sparing diet and brief fast on nitrogen metabolism in mildly obese subjects. J Lab Clin Med. 1977;89:1030–1035
  10. Vertes V, Genuth SM, Hazelton IM. Supplemented fasting as a large-scale outpatient program. JAMA. 1977;238:2151–2153
  11. Linn R, Stuart SL. The last chance diet. Secaucus, New Jersey: Lyle Stuart; 1976;
  12. Schucker RE, Gunn WJ. A national survey of the use of protein products in conjunction with weight reduction diets among American women. Atlanta: Center for Disease Control; 1978;
  13. DeHaven J, Sherwin R, Hendler R, Felig P. Nitrogen and sodium balance and sympathetic-nervous-system activity in obese subjects treated with a low-calorie protein or mixed diet. N Engl J Med. 1980;302:477–482
  14. Kelleher PC, Phinney SD, Sims EAH, et al.  Effects of carbohydrate-containing and carbohydrate-restricted hypocaloric and eucaloric diets on serum concentrations of retinolbinding protein thyroxine-binding prealbumin and transferrin. Metabolism. 1983;32:95–101
  15. Johnson RA, Baker SS, Fallon JT, et al.  An occidental case of cardiomyopathy and selenium deficiency. N Engl J Med. 1981;304:1210–1212
  16. Licata AA, Lantigua R, Amatruda J, Lockwood D. Adverse effects of liquid protein fast on the handling of magnesium, calcium and phosphorus. Am J Med. 1981;71:767–772
  17. Jones AO, Jacobs RM, Fry BE, Jones JW, Gould JH. Elemental content of predigested liquid protein products. Am J Clin Nutr. 1980;33:2545–2550

☆ This work was supported by a grant (RR 00044) from the General Clinical Research Centers Program of the Division of Research Resources and by a grant from the Delmark Company, Inc.

☆☆ This work was presented in part at the Meetings of the American Federation for Clinical Research, Boston, Massachusetts.

PII: 0002-9343(83)90804-5

The American Journal of Medicine
Volume 74, Issue 6 , Pages 1016-1022 , June 1983

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