The American Journal of Medicine
Volume 59, Issue 3 , Pages 334-342 , September 1975

Primary aldosteronism: A study in contrasts

  • M.G. Nicholls, M.B.

      Affiliations

    • Present address: MRC Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT Scotland.
    • From the Medical Unit, The Princess Margaret Hospital and Pathology Departments, Princess Margaret Hospital and Christchurch Hospital, Christchurch, New Zealand.
    • ,
  • E.A. Espiner, M.D.

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dr. E. A. Espiner.
    • From the Medical Unit, The Princess Margaret Hospital and Pathology Departments, Princess Margaret Hospital and Christchurch Hospital, Christchurch, New Zealand.
    • ,
  • H. Hughes, Ph.D.

      Affiliations

    • From the Medical Unit, The Princess Margaret Hospital and Pathology Departments, Princess Margaret Hospital and Christchurch Hospital, Christchurch, New Zealand.
    • ,
  • Janne Ross, B.Sc (Hons)

      Affiliations

    • From the Medical Unit, The Princess Margaret Hospital and Pathology Departments, Princess Margaret Hospital and Christchurch Hospital, Christchurch, New Zealand.
    • ,
  • D.T. Stewart, M.D.

      Affiliations

    • From the Medical Unit, The Princess Margaret Hospital and Pathology Departments, Princess Margaret Hospital and Christchurch Hospital, Christchurch, New Zealand.

,Accepted 9 December 1974.

References 

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  2. Baer L, Sommers SC, Krakoff LR, Newton MA, Laragh JH. Pseudoprimary aldosteronism. Circ Res 26. 1970;27(suppl I):203
  3. Omae T, Kawasaki T, Tanaka K, Arakawa K, Emoto K, Masaki J, et al. Hyperaldosteronism due to adrenocortical adenoma and adenomatous hyperplasia. Endocrinol Jap. 1971;18:57
  4. Christlieb AR, Espiner EA, Amsterdam EA, Jagger PI, Dobrzinsky SJ, Lauler DP, et al. The pattern of electrolyte excretion in normal and hypertensive subjects before and after saline infusions. Am J Cardiol. 1971;27:595
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  10. Drekter IJ, Heisler A, Scism GR, Stern S, Pearson S, McGavack TY. The determination of urinary steroids. I. The preparation of pigment-free extracts and a simplified procedure for the estimation of total 17-ketosteroids. J Clin Endocrinol Metab. 1952;12:55
  11. Metcalf MG. A rapid method for measuring 17-hydroxycorticosteroids in urine. J Endocrinol. 1963;26:415
  12. Metcalf MG. Gas Chromatographic assay of urinary pregnanediol. Anal Biochem. 1968;25:510
  13. Espiner EA, Beaven DW, Hart DS. Bioassay of corticotrophin using the sheeps transplanted adrenal gland. J Endocrinol. 1963;27:267
  14. Murphy BEP. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab. 1967;27:973
  15. Aitchison J, Brown JJ, Ferriss JB, Fraser R, Kay AW, Lever AF, et al. Quadric analysis in the preoperative distinction between patients with and without adrenocortical tumours in hypertension with aldosterone excess and low plasma renin. Am Heart J. 1971;82:660
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  17. Luetscher JA, Ganguly A, Melada G, Beckerhoff R. Preoperative distinction between hyperaktosteronism due to adenoma and bilateral hyperplasia. Clin Res. 1973;21:721
  18. Neville AM, Symington T. Pathology of primary aldosteronism. Cancer. 1966;19:1854
  19. Davignon J, Tremblay G, Nowaczynski W, Koiw E, Genest J. Parallel biochemical and histochemical studies of an adrenocortical adenoma from a patient with primary aldosteronism. Acta Endocrinol (Kbh). 1961;38:207
  20. Biglieri EG, Hane S, Slaton PE, Forsham PH. In vivo and in vitro studies of adrenal secretions in Cushing's syndrome and primary aldosteronism. J Clin Invest. 1963;42:516
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  24. Kawasaki T, Omae T, Tanaka K, Matsunaga M, Emoto K. Remission of recurrent hyperaldosteronism resulting from subtotal adrenalectomy of adenomatous hyperplastic adrenal glands. J Clin Endocrinol Metab. 1971;33:474
  25. Davis WW, Newsome HH, Wright LD, Hammond WG, Easton J, Bartter FC. Bilateral adrenal hyperplasia as a cause of primary aldosteronism with hypertension, hypokalemia and suppressed renin activity. Am J Med. 1967;42:642
  26. Gocke DJ, Gerten J, Sherwood LM, Laragh JH. Physiological and pathological variations of plasma angiotensin II in man. Circ Res 24. 1969;25(suppl I):131
  27. Ross PJ, Espiner EA, Hart DS. Variations in aldosterone secretion in sheep with cervical adrenal transplants. NZ Med J. 1973;78:364
  28. Biglieri EG, Schambelan M, Slaton PE, Stockigt JR. The intercurrent hypertension of primary aldosteronism. Circ Res 26. 1970;27(suppl I):195
  29. Brown JJ, Chinn RH, Düsterdieck GO, et al. Hypertension hyperaldosteronism with low plasma renin concentration: analysis of a series of eighty-two patients. In: 3rd ed. Proc R Soc Med. 62:1969;p. 1258
  30. Katz FH. Primary aldosteronism with suppressed plasma renin activity due to bilateral nodular adrenocortical hyperplasia. Ann Intern Med. 1967;67:1035

☆ This investigation was supported in part by the National Heart Foundation of New Zealand and the New Zealand Medical Research Council.

PII: 0002-9343(75)90391-5

The American Journal of Medicine
Volume 59, Issue 3 , Pages 334-342 , September 1975

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