Primary aldosteronism:☆
A study in contrasts
Abstract
Two patients with primary aldosteronism, one with a solitary adrenal adenoma and the other with bilateral nodular hyperplasia, are described. Both patients showed the classic features of primary aldosteronism in electrolyte and hormone patterns, but there were important differences in the biochemistry of their excised adrenal tissue. In addition, the injection of plasma from the patient with bilateral adrenal hyperplasia into the sheep's transplanted adrenal gland elicited a definite aldosterone secretory response, but there was no aldosterone response to the Injection of plasma from the patient with a solitary adrenal adenoma. The findings support the hypothesis that an extra-adrenal stimulus may contribute to the pathogenesis of bilateral adrenal hyperplasia.
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☆ This investigation was supported in part by the National Heart Foundation of New Zealand and the New Zealand Medical Research Council.
PII: 0002-9343(75)90391-5
© 1975 Published by Elsevier Inc.
