The American Journal of Medicine
Volume 59, Issue 3 , Pages 325-333, September 1975

Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis:☆

A new syndrome

  • Robert S. Dobrin, M.D.

      Affiliations

    • Present address: Box 271, The Rockefeller University, 66th Street and York Avenue, New York, New York 10021.
    • Minneapolis, Minnesota USA
    • From the Department of Pediatrics, Division of Pediatric Nephrology, University of Minnesota, Minneapolis, Minnesota.
    • ,
  • Robert L. Vernier, M.D.

      Affiliations

    • Minneapolis, Minnesota USA
    • From the Department of Pediatrics, Division of Pediatric Nephrology, University of Minnesota, Minneapolis, Minnesota.
    • ,
  • Alfred J. Fish, M.D. (Established Investigator)

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dr. Alfred J. Fish, University of Minnesota Medical School, Division of Pediatric Nephrology, Box 491, 13th Floor, Health Sciences Unit A, Minneapolis, Minnesota 55455.
    • American Heart Association Minneapolis, Minnesota USA
    • From the Department of Pediatrics, Division of Pediatric Nephrology, University of Minnesota, Minneapolis, Minnesota.

Accepted 1 November 1974.

Abstract 

We describe two patients with a unique granulomatous syndrome who presented with renal failure secondary to diffuse eosinophilic interstitial nephritis. Both had bilateral anterior uveltis, bone marrow granulomas, hypergammaglobulinemia and an increased sedimentation rate. One patient had lymph node granulomas and an immunoglobulin G (IgG) rheumatoid factor. An extensive investigation for an etiologic agent was unrewarding, and neither patient could be placed into any existing diagnostic category. Over a period of 2 years both patients have experienced improved renal function and dissolution of their bone marrow granulomas

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☆ This study was supported by Grants AI 10704 and HL 06314 from the National Institutes of Health, Bethesda, Maryland.

PII: 0002-9343(75)90390-3

The American Journal of Medicine
Volume 59, Issue 3 , Pages 325-333, September 1975

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