The American Journal of Medicine
Volume 59, Issue 3 , Pages 316-324, September 1975

Morphology of chronic lymphocytic leukemia and its relationship to survival☆

  • LoAnn C. Peterson, M.D.

      Affiliations

    • From the Department of Laboratory Medicine and Pathology, and Section of Medical Oncology. University of Minnesota Health Sciences Center, Minneapolis, Minnesota 55455.
    • ,
  • Clara D. Bloomfield, M.D.

      Affiliations

    • From the Department of Laboratory Medicine and Pathology, and Section of Medical Oncology. University of Minnesota Health Sciences Center, Minneapolis, Minnesota 55455.
    • ,
  • R.Dorothy Sundberg, Ph.D., M.D.

      Affiliations

    • From the Department of Laboratory Medicine and Pathology, and Section of Medical Oncology. University of Minnesota Health Sciences Center, Minneapolis, Minnesota 55455.
    • ,
  • K.J. Gajl-Peczalska, M.D.

      Affiliations

    • From the Department of Laboratory Medicine and Pathology, and Section of Medical Oncology. University of Minnesota Health Sciences Center, Minneapolis, Minnesota 55455.
    • ,
  • Richard D. Brunning, M.D.

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dr. Richard D. Brunning, Box 198, University of Minnesota Hospital, Minneapolis, Minnesota 55455.
    • From the Department of Laboratory Medicine and Pathology, and Section of Medical Oncology. University of Minnesota Health Sciences Center, Minneapolis, Minnesota 55455.

Minneapolis, Minnesota USA

Accepted 28 February 1975.

Abstract 

The morphology of lymphocytes in blood and bone marrow from patients with chronic lymphocytic leukemia was studied; blood lymphocyte morphology was related to survival. Three primary morphologic groups emerged. Group I was characterized by small to medium-sized lymphocytes with narrow rims of cytoplasm and coarsely clumped nuclear chromatin. In group II the predominant lymphocytes were large with abundant cytoplasm. Group III was characterized by a heterogeneous population of lymphocytes with characteristics of both groups I and II. Clinical features of the patients were studied, and B and T typing of the lymphocytes was done. The median survival in group I was 26+ months; In group II 46+ months; and in group III 50+ months. Our data are at variance with previous reports and suggest that survival in patients with large lymphocytes Is longer than in those with small lymphocytes.

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☆ This study was supported in part by Grant CA 08832 from the National Cancer Institute of the U.S. Public Health Service, the Leukemia Research Fund, Inc., and the American Cancer Society.

PII: 0002-9343(75)90389-7

The American Journal of Medicine
Volume 59, Issue 3 , Pages 316-324, September 1975

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