The American Journal of Medicine
Volume 43, Issue 5 , Pages 795-803, November 1967

Recurrent cholestatic jaundice of pregnancy with demonstrated estrogen sensitivity

    M.D.
  • Mary Jeanne Kreek

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Dr. Mary Jeanne Kreek, New York Hospital, 525 E. 68th Street, New York, New York 10021.
    • From the Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, New York.
    • Supported by a Postdoctoral Research Fellowship, U. S. Public Health Service F2 A.M.-30, 036.
    • ,
  • Marvin H. Sleisenger, M.D.

      Affiliations

    • Supported by a Postdoctoral Research Fellowship, U. S. Public Health Service F2 A.M.-30, 036.
    • From the Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, New York.
    • ,
  • Graham H. Jeffries, M.R.C.P.

      Affiliations

    • From the Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, New York.

New York, New York USA

Received 4 November 1966

Abstract 

Described herein is a patient with cholestatic jaundice which recurred during each of eight (or nine) pregnancies. Similar episodes of jaundice were associated with abnormal menses (menorrhagia). Following delivery or with the onset of menstruation the patient became asymptomatic, and liver function returned to normal. Liver biopsies showed intrahepatic cholestasis during pregnancy, and a return to normal after pregnancy. An identical clinical picture with jaundice and abnormal liver function tests was induced when the patient was challenged with the synthetic estrogen, estinyl estradiol (1 mg. daily).

This patient is presented as a case of idiopathic recurrent cholestatic jaundice of pregnancy. The evidence that this entity may have a hormonal basis is discussed.

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PII: 0002-9343(67)90122-2

The American Journal of Medicine
Volume 43, Issue 5 , Pages 795-803, November 1967

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