Attempts at transplantation of human bone marrow in patients with acute leukemia and other marrow depletion disorders☆
Abstract
1.1. Twenty-six attempts at transplantation of human bone marrow obtained from excised bones were carried out in nineteen patients with acute leukemia and other marrow depletion syndromes with or without preliminary treatment with total body radiation. There was no evidence of a permanent “take” after any of the attempts, although signs of transient functioning of the marrow appeared in three instances.
2.2. Four additional patients received marrow aspirated from living donors (two homologous and two autologous). One patient with reticulum cell sarcoma underwent a relatively long remission after receiving 100 mg. of nitrogen mustard, followed by injection of her own preserved marrow.
3.3. The course of the patients with acute leukemia did not in general seem to be altered significantly by radiation and injections of marrow. The explored sources of procurement and methods of processing and administering marrow from excised bones may provide a basis for the utilization of human marrow in future attempts to transplant bone marrow.
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Philadelphia, Pennsylvania, USA
☆ This study was aided by a grant, AT(30-1)-1982, from the Division of Biology of the Atomic Energy Commission.
1 From the Charlotte Drake Cardeza Foundation, Jefferson Medical College, Philadelphia, Pennsylvania.
ABSTRACT